Author

Austin D. Silva

University of California, IrvineORCID 0000-0001-5150-2551Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Assay:multiome· 1

Frequent Co-Authors

Christopher J. HalbrookiD· 2 shared Rima SinghiD· 2 shared Albrecht StenzingeriD· 1 shared Alexander KlegeriD· 1 shared Alica K. Beutel· 1 shared Alica K. MichelsiD· 1 shared Alireza AbaeiiD· 1 shared Anna HärleiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

Christopher J. HalbrookORCID

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2 papers

Recent·Most cited

Cancer BiologyCellular and Molecular Gastroenterology and HepatologyPeer-reviewedSep 5, 2026

Comparative Analysis of Primary and Liver Fibroblasts Reveals MET as a Potent Target in Pancreatic Cancer Metastasis

Rima Singh, Natalie Yousefian, Walker M. Allen…·Christopher J. Halbrook

The paper compares primary and liver PDAC lesions using single-cell transcriptomics to identify MET as a target in pancreatic cancer metastasis.

1 citation

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Cancer BiologybioRxivPreprintSep 16, 2025

Exploiting TGF-β-mediated Stromal Programming in Homologous Recombination-Deficient Pancreatic Cancer

Élodie Roger, Hannah M Mummey, Eleni Zimmer…·Alexander Kleger

This study shows that ATM-deficient pancreatic cancers reprogram the tumor microenvironment via TGF-β-driven myCAF enrichment, and targeting this stromal axis with chemotherapy improves therapeutic efficacy.

DOI 10.1101/2025.09.16.676458

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