ImmunologyCardiovascular ResearchPeer-reviewed
Lipopolysaccharide Induces Trained Innate Immune Tolerance in the Heart Through Interferon Signaling in a Model of Stress-Induced Cardiomyopathy
Kenji Rowel Q. Lim, Junedh Amrute, Attila D Kovács…·Douglas L. Mann
This study shows that LPS pretreatment protects hearts from ISO-induced injury through TLR4-mediated interferon signaling, involving both cell-autonomous and non-cell-autonomous mechanisms.