This study shows that LPS pretreatment protects hearts from ISO-induced injury through TLR4-mediated interferon signaling, involving both cell-autonomous and non-cell-autonomous mechanisms.

Cardiovascular Research · Sep 9, 2025Peer-reviewedImmunology

Targeting RUNX1 in Macrophages Facilitates Cardiac Recovery

Junedh Amrute, Ada Zhu, Yun-Ling Pai, Melissa Hector-Greene, Yuqian An, Kenji Rowell Kim, Maya U. Sheth, Arun Padmanabhan, Clara Youngna Lee, Tracy Yamawaki, Florian Sicklinger, Niklas Hartman, Andrea L. Bredemeyer, Chang Jie Mick Lee, Vee Xu, , Kory J. Lavine

This study identifies RUNX1 as a key regulator of cardiac recovery by reprogramming macrophages, showing that its inhibition promotes heart function recovery in a chronic heart failure model.

bioRxiv · Jul 25, 2025 · PreprintImmunology

Defining Cardiac Recovery at Single Cell Resolution

Junedh Amrute, Lulu Lai, Pan Ma, Andrew L. Koenig, Kenji Kamimoto, Andrea L. Bredemeyer, Thirupura Sundari Shankar, Christoph Kuppe, Farid F. Kadyrov, Linda Schulte, Dylan Stoutenburg, Benjamin J. Kopecky, Sutip Navankasattusas, Joseph R. Visker, Samantha A. Morris, , Kory J. Lavine

The paper defines the cellular and transcriptional features of cardiac recovery using snRNA-seq, identifying RUNX1 downregulation as a key predictor and potential therapeutic target.

bioRxiv · Sep 11, 2022 · PreprintGenomics