Lenny Malihan‐Yap

This paper engineers a membrane-bound alkane monooxygenase to improve its activity in selectively hydroxylation of linear and branched aliphatic esters, achieving stereoselectivity and expanding substrate range.

The paper engineers transmembrane alkane monooxygenases to improve terminal hydroxylation of isoprenyl acetate, enabling fermentative production of tulipalin A from renewable resources.

The paper demonstrates that a heterologous electron sink outcompetes natural electron transport pathways in engineered cyanobacteria, revealing FNR as the preferred route for electron delivery and highlighting the NADPH/NADP+ ratio's role in electron flux.