Elske van der Pol

Ancestral sequence reconstruction of a bacterial decarboxylase gave enzymes with up to 294-fold longer half-life at 45 °C, higher activity, and 99.7% ee on a vinyl malonate substrate.

This paper engineers a membrane-bound alkane monooxygenase to improve its activity in selectively hydroxylation of linear and branched aliphatic esters, achieving stereoselectivity and expanding substrate range.

This study modifies arylmalonate decarboxylase to expand its substrate scope for synthesizing (R)-enantiomers of sterically hindered carboxylic acids with high enantiopurity.