Author
Broad InstituteORCID 0000-0003-2335-7793Unclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Juliana E Gentile, Jonathan E. Farley, Margaret N. Kelemen…·Eric Vallabh Minikel
This study demonstrates that deep PrP lowering with a potent siRNA prevents prion disease symptoms in mice and extends survival in symptomatic animals.
Juliana E Gentile, Taylor L Corridon, Fiona E. Serack…·Sonia M. Vallabh
Divalent siRNA 2439-s4 lowers human PrP to 17% residual in transgenic mouse brain after one dose, and a separate mouse Prnp-targeting siRNA extends survival in prion-infected mice.
Shih-Wei Chou, Meredith A Mortberg, Kimberly Marlen…·Bryan Zeitler
This study demonstrates that Zinc Finger Repressors (ZFRs) reduce prion protein (PrP) expression in nonhuman primates and extend survival in prion disease mice.