Fiona E. Serack

The paper describes BI-TfR1 CapX, a gene delivery vector that efficiently crosses the blood-brain barrier, transduces CNS neurons and astrocytes, and reduces Prnp mRNA with low doses.

The paper measures PrP half-life in vivo and shows it limits the time to effect of PrP-lowering therapies, with implications for drug development and clinical trial design.

Divalent siRNA 2439-s4 lowers human PrP to 17% residual in transgenic mouse brain after one dose, and a separate mouse Prnp-targeting siRNA extends survival in prion-infected mice.

This study shows syngeneic adipose-derived stromal cells (ASCs) modulate early macrophage responses but are cleared by 2 weeks in DAT implants, with no long-term regenerative impact.

This study evaluates how different polysaccharide hydrogel compositions affect the viability and pro-angiogenic function of human adipose-derived stromal cells in vitro and in vivo.