Deanna M. Pepin

The paper engineers a gut bacterium to enhance osmotic resistance, enabling it to survive malabsorption in industrialized microbiomes.

This study shows that bowel preparation with PEG increases susceptibility to pathogens and exacerbates inflammation in mouse and in vitro models.

PUPpy designs taxon-specific primers for substrain-level microbial detection and absolute quantification, outperforming 16S rRNA and shotgun sequencing in defined communities.