Imogen Porter

Modeling herpes simplex virus type 2 and Zika virus replication in vaginal organoids and spheroids

This study shows that vaginal organoids support HSV-2 and ZIKV replication and respond to antiviral drugs, with differences in drug efficacy between mouse organoids and human spheroids.

In mouse and in vitro models, bowel preparation promotes pathogen colonization, translocation and exacerbation of inflammation

This study shows that bowel preparation with PEG increases susceptibility to pathogens and exacerbates inflammation in mouse and in vitro models.

Transposon wave remodelled the epigenomic landscape in the rapid evolution of a novel X chromosome dosage compensation mechanism

The paper identifies a recent transposon wave that remodelled the X chromosome epigenome, leading to a novel dosage compensation mechanism in Poecilia picta.