Rajiv Jesudason

The paper identifies a novel class of mature lymphoid aggregates in NSCLC using spatial proteomics and develops a classifier to improve CPI biomarker eligibility.

This study uses single-cell and spatial profiling to show that inflammatory signals from macrophages and fibroblasts drive CD8 T cell exhaustion and resistance to immune checkpoint blockade in prostate cancer.

The paper develops a framework to decode TLS maturation in NSCLC using spatial omics data and deep learning, identifying two distinct spatial ecosystems linked to patient outcomes.

SPEX provides a web-based platform for spatial omics analysis, enabling modular and user-friendly processing of spatial transcriptomics and proteomics data.

PerturbView enables highly multiplexed optical pooled screens in primary cells and tissues by improving barcode amplification, revealing regulators of NFκB signaling and enabling spatial transcriptomics integration.