Author

Frank Peale

Genentech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioinformatics· 1 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1 Approach:deep learning· 1

Frequent Co-Authors

Danilo MaddaloiD· 2 shared Lisa M. McGinnisiD· 2 shared Rajiv JesudasoniD· 2 shared Sandra RostiD· 2 shared Abbas NaziriD· 1 shared Alexander Prilipko· 1 shared Anna ShemorryiD· 1 shared Artem Zubkov· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

Danilo MaddaloORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Spatiotemporal profiling reveals the role of inflammatory niche in driving prostate cancer

Abbas Nazir, Hanchen Wang, Ziyu Lu, Jeffrey Lau, Frank Peale, Rajiv Jesudason, Kelli A. Connolly, Žaneta Andrusivová, Julia Lau, Sarah Gierke, Linna Peng, Sara Chan, Jian Jiang, Sandra Rost, Eric Lubeck, , Aviv Regev

This study uses single-cell and spatial profiling to show that inflammatory signals from macrophages and fibroblasts drive CD8 T cell exhaustion and resistance to immune checkpoint blockade in prostate cancer.

bioRxiv · Apr 22, 2026 · PreprintCancer Biology

Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

Anna Shemorry, Willem den Besten, Melinda M. Mulvihill, Curt J. Essenburg, Nicole Blaquière, Tracy Kleinheinz, Elisia Villemure, Frank Peale, Gauri S. Deshmukh, Danilo Maddalo, Elizabeth Levy, Kebing Yu, Matthew R. Steensma, Elizabeth A. Tovar, Emily Wolfrum, , Ingrid E. Wertz

This study evaluates bifunctional ER degraders with different ubiquitin ligase ligands, finding that pan-IAP antagonists enhance ER degradation and induce TNF-dependent cell death more effectively than existing therapies.

Cell chemical biology · May 1, 2025Peer-reviewedCancer Biology

SPEX: A modular end-to-end platform for high-plex tissue spatial omics analysis

Xiao Li, Ximo Pechuan-Jorge, Tyler Risom, Conrad Foo, Alexander Prilipko, Artem Zubkov, Caleb K. Chan, Patrick S. Chang, Frank Peale, James M. Ziai, Sandra Rost, Derrek P. Hibar, Lisa M. McGinnis, Evgeniy Tabatsky, Xin Ye, , Rajiv Jesudason

SPEX provides a web-based platform for spatial omics analysis, enabling modular and user-friendly processing of spatial transcriptomics and proteomics data.

GigaScience · Jan 1, 2025Peer-reviewedBioinformatics

The Jag2/Notch1 signaling axis promotes sebaceous gland differentiation and controls progenitor proliferation

Syeda Nayab Fatima Abidi, Sara M. Chan, Kerstin Seidel, Daniel Lafkas, Louis Vermeulen, Frank Peale, Christian W. Siebel

This study identifies the Jag2/Notch1 signaling axis as critical for sebaceous gland differentiation and progenitor cell regulation in adult skin.

bioRxiv · May 5, 2024Developmental Biology