Author

James G. Dowty

The University of MelbourneORCID 0000-0003-2383-0886Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

A.C. Bakker· 1 shared A.S. van der Werf – ‘t LamiD· 1 shared Anja WagneriD· 1 shared Aung Ko WiniD· 1 shared Catherine Elizabeth CaldoniD· 1 shared Christie J. van AspereniD· 1 shared Ellis L. Eikenboom· 1 shared Encarna B. Gómez-GarcíaiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

A.C. Bakker

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Genetic & Genomic MedicinemedRxivPreprintFeb 15, 2025

Cancer risks for MSH6 pathogenic variant carriers

A.S. van der Werf – ‘t Lam, James G. Dowty, Morrison Italia…·Maartje Nielsen

This study provides cancer risk estimates for MSH6 pathogenic variant carriers, identifying elevated risks for specific cancers like endometrial and ovarian cancer.

DOI 10.1101/2025.02.15.25322330

humanstatistical model

𝕏 PostBluesky

GeneticsNature CommunicationsPeer-reviewedDec 1, 2024

SAM-DNMT3A, a strategy for induction of genome-wide DNA methylation, identifies DNA methylation as a vulnerability in ER-positive breast cancers

Mahnaz Hosseinpour, Xinqi Xi, Ling Liu…·Joseph Rosenbluh

The paper introduces SAM-DNMT3A, a CRISPR-based method to induce global DNA methylation, and shows it exploits a vulnerability in ER-positive breast cancers.

6 citations

humanDNA methylation

𝕏 PostBluesky