The farnesyl transferase inhibitor KO-2806 re-sensitizes relapsing tumors to RAS inhibition
Hetika Vora Patel, Alison Elizabeth Smith, Stacia Chan, Jovylyn Gatchalian Gasendo, Ayuna Jombik, John Edward Greer, Tejas Samantaray, Linda V. Kessler, Amitava Mitra, Xuefeng Zhu, Yahu A. Liu, Francis J. Burrows, Shivani Malik
This paper identifies mTORC1 activity as a driver of resistance to RAS inhibitors and shows that KO-2806 re-sensitizes resistant tumors to RAS inhibition.
Cancer Research · Feb 9, 2026Peer-reviewedCancer Biology