Author

Jan Detleffsen

Max Planck Institute for Heart and Lung ResearchORCID 0000-0003-2401-1444Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:scATAC-seq· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Mario LoosoiD· 3 shared Carsten Tobias KuenneiD· 2 shared Mette Skou BentseniD· 2 shared Agatha Ribeiro da SilvaiD· 1 shared Angeline UsanayoiD· 1 shared Armaan MehraiD· 1 shared Brenton BrunsiD· 1 shared Didier Y. R. StainieriD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBioinformatics

Mario LoosoORCID

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3 papers

Recent·Most cited

BioinformaticsiSciencePeer-reviewedJun 29, 2026

SC-Framework: A robust and FAIR semi-interactive environment for single-cell resolution datasets

Hendrik Schultheis, Jan Detleffsen, René Wiegandt…·Mario Looso

SC-Framework provides a unified, containerized environment for single-cell data analysis to improve reproducibility and scalability.

3 citationstop 5%

scRNA-seqexperimental assay

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BioinformaticsbioRxivPreprintFeb 20, 2025

PEAKQC: Periodicity Evaluation in scATAC-seq data for quality assessment

Jan Detleffsen, Carsten Tobias Kuenne, Mette Skou Bentsen, Mario Looso

PEAKQC evaluates single-cell ATAC-seq quality using wavelet-based convolution of fragment length distribution patterns, improving downstream analysis by filtering low-quality cells.

DOI 10.1101/2025.02.20.639146

scATAC-seqstatistical model

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Molecular BiologyDevelopmentPeer-reviewedNov 29, 2024

flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response

Zhenyu Wang, Armaan Mehra, Qianchen Wang…·Rubén Marín‐Juez

This study shows that inactivating flt1 in zebrafish enhances cardiac regeneration by improving vascularization and reducing fibrosis.

11 citations

zebrafishbulk RNA-seq

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