Olivier François

The paper tests if climate-associated genomic variation predicts phenotypic adaptation in European wild apple, finding genomic offsets link to bud-break timing but not other traits.

The paper develops HDMAX2, a method for high-dimensional mediation analysis, and applies it to study the indirect effects of maternal smoking on birth outcomes via placental DNA methylation.

This paper introduces sparse latent factor regression models for genome-wide and epigenome-wide association studies, showing improved statistical performance and robustness in both simulated and real data applications.

LFMM 2.0 improves confounder adjustment in genome and epigenome-wide association studies using latent factor models, outperforming existing methods in simulations and providing new insights into disease mechanisms.