Barbara Heude

This study constructs a high-resolution placental mQTL resource and investigates how placental DNA methylation relates to early- and later-life traits and their shared vulnerability.

The paper conducts a multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycemic traits, identifying novel loci and highlighting limited pregnancy-specific genetic effects.

This study identifies genetic variants associated with urinary phthalate metabolite levels in children through GWAS and CNV analysis.

The paper develops HDMAX2, a method for high-dimensional mediation analysis, and applies it to study the indirect effects of maternal smoking on birth outcomes via placental DNA methylation.

This paper introduces sparse latent factor regression models for genome-wide and epigenome-wide association studies, showing improved statistical performance and robustness in both simulated and real data applications.

This study identifies placental DNA methylation changes linked to maternal smoking during pregnancy and their associations with birth outcomes using data from the PACE consortium.

This study identifies 344 differentially methylated regions in placental DNA linked to maternal smoking, including reversible and persistent changes in former smokers.

This study identifies genetic loci associated with early childhood growth phenotypes and links them to later adiposity traits, suggesting potential targets for obesity prevention.