Johanna Lepeule

This study constructs a high-resolution placental mQTL resource and investigates how placental DNA methylation relates to early- and later-life traits and their shared vulnerability.

The paper develops HDMAX2, a method for high-dimensional mediation analysis, and applies it to study the indirect effects of maternal smoking on birth outcomes via placental DNA methylation.

This paper identifies 39,749 autosomal cis-eQTMs in children's blood using HELIX data, showing most are near genes and many have genetic variants associated with methylation and expression.

This paper introduces sparse latent factor regression models for genome-wide and epigenome-wide association studies, showing improved statistical performance and robustness in both simulated and real data applications.

This study identifies placental DNA methylation changes linked to maternal smoking during pregnancy and their associations with birth outcomes using data from the PACE consortium.

This study identifies 344 differentially methylated regions in placental DNA linked to maternal smoking, including reversible and persistent changes in former smokers.