Developmental BiologyNature CommunicationsPeer-reviewed
Altered Extracellular Matrix Structure and Elevated Stiffness in a Brain Organoid Model for Disease
Maayan Karlinski Zur, Bidisha Bhattacharya, Inna Solomonov…·Orly Reiner
This study shows that LIS1 mutations in brain organoids lead to increased tissue stiffness and altered ECM structure, with a computational model predicting mechanical changes.
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