Altered Extracellular Matrix Structure and Elevated Stiffness in a Brain Organoid Model for Disease
Maayan Karlinski Zur, Bidisha Bhattacharya, Inna Solomonov, Sivan Ben Dror, Alon Savidor, Yishai Levin, Amir Prior, Tamar Sapir, Talia Harris, Tsviya Olender, Rita Schmidt, JM Schwarz, Irit Sagi, Amnon Buxboim, Orly Reiner
This study shows that LIS1 mutations in brain organoids lead to increased tissue stiffness and altered ECM structure, with a computational model predicting mechanical changes.
Nature Communications · May 1, 2025Peer-reviewedDevelopmental Biology