Oren Ram

The paper introduces COMPACT promoters for tunable and robust gene expression in mammalian cells, showing they outperform native promoters under stress conditions.

sc-rDSeq improves single-cell RNA sequencing by capturing full-length total RNA, revealing hidden heterogeneity and non-polyA RNA variations in lung cancer cells.

The paper shows that key pluripotency TFs exhibit bimodal DNA binding preferences based on GC-content and STRs, while c-Myc binding is dominated by GC-content and STRs in high-GC regions.

This study shows that germline manipulation in killifish leads to sex-specific effects on longevity and repair mechanisms.

The paper identifies enhancer-specific DNA methylation variations during mouse embryonic stem cell differentiation using combined histone mark and methylation analysis.

CloneSeq identifies rare cell subpopulations by combining clonal expansion with single-cell RNA-seq, revealing cancer stem-like cells and improved stemness in embryonic cells.

This study shows Esrrb promotes XEN differentiation in G2/M phase ESCs and is required for XEN differentiation potential, while its absence leads to loss of differentiation capacity.

The paper shows that DNA sequence repeat symmetry defines transcription factor and histone modification binding preferences across developmental layers in human embryonic stem cells.