Inna Solomonov

The paper shows that persistent ECM scarring in the colon reprograms intestinal stem cells to drive chronic inflammation through a modECM niche.

This study shows that LIS1 mutations in brain organoids lead to increased tissue stiffness and altered ECM structure, with a computational model predicting mechanical changes.

The paper identifies a pre-symptomatic extracellular-matrix signature in colitis models and validates it in human subjects, showing its mediation by neutrophils and monocytes.