Amartya Singh

This study shows that BLTP3A dysfunction leads to lysosomal stress, which activates STING and promotes antitumor immunity by sustaining IFN-λ production in ovarian cancer.

This study shows dedifferentiation-derived oncogenic stem cells sustain intestinal tumorigenesis more effectively than mutant stem cells, with aberrant Notch signaling and metabolic plasticity contributing to tumor growth.

This study identifies histidine depletion as an antileukemic strategy in T-ALL by revealing its role in suppressing cholesterol biosynthesis through ribosome stalling and GCN2 activation.

The paper identifies a distinct breast tumor group with monoallelic gene expression linked to poor prognosis and develops a method to detect allelic imbalance.

This paper introduces the average overlap metric to improve clustering and annotation in single-cell RNA sequencing by comparing gene rankings across clusters.

The paper introduces a revised workflow for scRNA-seq analysis that performs feature selection before normalization, leading to improved clustering results.

TuBA identifies clinically relevant tumor transcriptional profiles in breast cancer by detecting biclusters with significant gene set agreement and clinical implications across multiple datasets.