Daniel Herranz

This paper identifies IMPDH as a therapeutic target in PTEN-deficient T-ALL, showing IMPDH inhibitors selectively kill these cells and extend survival in mouse models.

This study identifies histidine depletion as an antileukemic strategy in T-ALL by revealing its role in suppressing cholesterol biosynthesis through ribosome stalling and GCN2 activation.

This paper introduces the average overlap metric to improve clustering and annotation in single-cell RNA sequencing by comparing gene rankings across clusters.

This study compares metabolic changes in acute and chronic LCMV infection using metabolomics and isotope tracing, finding more dramatic changes in chronic infection and altered thymidine metabolism as a marker.