Author

Eva‐Doreen Pfister

Medizinische Hochschule HannoverORCID 0000-0003-2446-4304Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

Alex BastianelliiD· 1 shared Amelie StalkeiD· 1 shared Annika BehrendtiD· 1 shared Carola DrögeiD· 1 shared Holger GohlkeiD· 1 shared Jan StindtiD· 1 shared Kathrin Grau· 1 shared Malte SgoddaiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperPhysiology

Alex BastianelliORCID

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1 paper

Recent·Most cited

PhysiologyJournal of Biological ChemistryPeer-reviewedSep 29, 2025

Impaired transitioning of the FXR ligand binding domain to an active state underlies an FXR-associated PFIC phenotype

Annika Behrendt, Alex Bastianelli, Jan Stindt…·Holger Gohlke

This study identifies a missense variant in FXR that impairs its conformational transition to an active state, leading to reduced BSEP expression and a PFIC phenotype.

4 citations

humanorganoid / primary culture

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