Annika Behrendt

This study identifies a missense variant in FXR that impairs its conformational transition to an active state, leading to reduced BSEP expression and a PFIC phenotype.

Vasor is a machine learning model that accurately predicts the pathogenicity of MDR3 missense variants, outperforming existing tools and providing a webserver for predictions.

The paper identifies specific phosphorylation sites on soluble tau oligomers in early Alzheimer’s disease that differ from those in neurofibrillary tangles.

The paper identifies a novel tau cleavage site at N167 by AEP in microglia, showing it is part of a proteolytic cascade leading to tau degradation, not accumulation.