Author

Mercedes Lachén‐Montes

NavarrabiomedORCID 0000-0003-2449-8117Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Assay:proteomics· 4 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Enrique SantamaríaiD· 4 shared Joaquín Fernández‐IrigoyeniD· 4 shared Paz Cartas‐CejudoiD· 3 shared Elena Anaya‐CuberoiD· 2 shared Leire ExtramianaiD· 2 shared Marina De Miguel· 2 shared Silvia Romero-MurilloiD· 2 shared Adriana CortésiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersNeuroscience

Enrique SantamaríaORCID

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4 papers

Recent·Most cited

NeuroscienceBrain PathologyPeer-reviewedAug 30, 2026

Olfactory proteomics reveals the capacity of the HDAC1 inhibitor pyroxamide to halt the α-synuclein preformed fibrils-induced damage in nasal epithelial, microglial and dopaminergic neuronal cell lines

Paz Cartas‐Cejudo, Marina De Miguel, Leire Extramiana…·Enrique Santamaría

The paper uses proteomic analysis of the olfactory tract to identify pyroxamide, an HDAC1 inhibitor, as a potential therapeutic for Parkinson's disease by reducing α-synuclein fibril-induced toxicity in cell lines.

DOI 10.1111/bpa.70140

humanproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintNov 26, 2025

Early, sex-dependent and progressive proteomic imbalance in the amygdala during Alzheimers disease progression

Silvia Romero-Murillo, Mercedes Lachén‐Montes, Paz Cartas‐Cejudo…·Enrique Santamaría

This study identifies sex-dependent and progressive proteomic changes in the amygdala across Alzheimer's disease stages, revealing potential sex-specific biomarkers and therapeutic targets.

DOI 10.1101/2025.11.26.690815

humanproteomics

𝕏 PostBluesky

NeurosciencebioRxivPreprintOct 1, 2023

Neuropathological stage-dependent proteome mapping of the olfactory tract in Alzheimer's disease: From early olfactory-related omics signatures to computational repurposing of drug candidates

Paz Cartas‐Cejudo, Adriana Cortés, Mercedes Lachén‐Montes…·Enrique Santamaría

This paper identifies stage-dependent proteomic changes in Alzheimer's disease olfactory tract and uses computational methods to repurpose drugs that can reverse early AD-related omics signatures.

DOI 10.1101/2023.10.01.560342

humanproteomics

𝕏 PostBluesky

Systems BiologyFrontiers in ImmunologyPeer-reviewedSep 8, 2022

Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions

Mercedes Lachén‐Montes, Naroa Mendizuri, Karina Ausín…·Enrique Santamaría

The paper investigates how SARS-CoV-2 structural proteins affect metabolic and immunological processes in mouse olfactory bulb cells, identifying TGF-beta signaling as a key activation node.

2 citations

mouseproteomics

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