Scott M. Coyle

The paper introduces RIPPLE, a synthetic system that uses reaction-diffusion waves to generate tunable subcellular structures by coupling IDR sequences to a two-protein RD circuit.

This paper develops light-controlled chemomechanical networks using Tcb2 protein to achieve rapid, repeatable actuation and dynamic self-assembly.

The paper describes a self-organizing circuit in Podophrya collini that optimizes predatory trap structure through adaptive scaling of tentacle number and length.

This study uses optical calcium release to investigate Tcb2 self-assembly in Tetrahymena, identifying D184 as the key calcium binding site for assembly.

The paper experimentally defines and models phase portraits of genetically encoded oscillators in yeast, showing how noise influences frequency and amplitude, enabling noise-guided design of synthetic protein dynamics.

This paper develops a genetically encoded protein oscillator system for real-time single-cell data streaming, demonstrating its use in tracking developmental states during differentiation.

This paper introduces a programmable reaction-diffusion system using MinD and MinE proteins to engineer spatiotemporal signaling in mammalian cells, enabling frequency-barcoded fluorescence signals for analyzing cellular activities.

The paper quantifies cell dynamics by analyzing shape fluctuations on micropatterned substrates, revealing statistical patterns that distinguish cell types and environmental effects.

This paper introduces synthetic MAP-IDR condensates (synMAPs) that enable tunable and regulatable assembly of microtubule structures in vitro and in mammalian cells.

Analysis of millions of unique cellular morphologies of the highly dynamic single-celled predator Lacrymaria olor reveals that it programs a comprehensive search space and emergent hunting behavior through coupling surface based active cilia and cortex based contractile molecular systems together.