Author

Nithesh P. Chandrasekharan

University of Wisconsin–MadisonORCID 0009-0004-9826-6823Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:imaging· 1 Assay:protein sequence· 1 Research Focus:software / tool· 1 Approach:statistical model· 1

Frequent Co-Authors

Jerry E. Honts· 2 shared M. Saad BhamlaiD· 2 shared Scott M. CoyleiD· 2 shared Xiangting Lei· 2 shared Aaron R. DinneriD· 1 shared Carlos FloydiD· 1 shared Laura Casas-Ferrer· 1 shared Tuhin ChakraborttyiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersBioengineering

Jerry E. Honts

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BioengineeringNature CommunicationsPeer-reviewedFeb 21, 2026

Light-induced assembly and repeatable actuation in Ca2+-driven chemomechanical protein networks

Xiangting Lei, Carlos Floyd, Laura Casas-Ferrer…·M. Saad Bhamla

This paper develops light-controlled chemomechanical networks using Tcb2 protein to achieve rapid, repeatable actuation and dynamic self-assembly.

2 citations

protein sequencedeep learning

𝕏 PostBluesky

BiophysicsJournal of Biological ChemistryPeer-reviewedOct 16, 2025

Decoding ultrasensitive self-assembly of the calcium-regulated Tetrahymena cytoskeletal protein Tcb2 using optical actuation.

Nithesh P. Chandrasekharan, Xiangting Lei, Jerry E. Honts…·Scott M. Coyle

This study uses optical calcium release to investigate Tcb2 self-assembly in Tetrahymena, identifying D184 as the key calcium binding site for assembly.

3 citations

imagingexperimental assay

𝕏 PostBluesky