Rachael D. Seidler

This study examines network segregation in older adults and finds it correlates with walking speed and working memory, with higher segregation linked to better physical function.

This study examines how uneven terrain and dual-task walking affect walking speed in older adults, finding that sensorimotor function better predicts changes in uneven terrain walking speed than cognitive function.

This study examines age differences in brain activity during uneven terrain walking, finding greater gait variability and reduced cortical modulation in older adults.

This study measures electrocortical activity during walking on uneven terrain and varying speeds, finding distinct brain region responses to terrain difficulty and speed.

This study examines how artificial gravity affects brain functional connectivity during bed rest, finding differential changes in somatosensory regions and mobility outcomes between groups receiving continuous vs. intermittent artificial gravity.

This study examines how spaceflight duration and prior experience affect brain structure in astronauts, finding greater ventricular expansion and white matter decline with longer missions and more prior flights.

This study shows that daily artificial gravity reduces brain activation during sensorimotor adaptation compared to head-down tilt bed rest.

This study examines how brain structure relates to balance in young and older adults under different sensory conditions, finding associations between cortical thickness, gyrification, and white matter microstructure with balance performance.

This study examines how brain structure relates to dual task walking in young and older adults, finding age-specific associations between brain atrophy and gait performance during cognitive tasks.

This study examines how long-duration spaceflight affects sensorimotor control and cognition, finding transient declines in mobility, balance, and bimanual coordination that recover within 30 days, while cognitive performance remains stable.

This study examines how spaceflight affects MRI-visible perivascular spaces (PVSs) in astronauts, finding that novice astronauts show increased PVS volume post-flight, while experienced astronauts show baseline correlations between flight days and PVS length.

This study examines resting-state functional connectivity changes in a spaceflight analog, finding distinct patterns in those who develop optic disc edema compared to those who do not.

This study finds higher brain glutathione levels in older adults and links sensorimotor GSH to poorer motor performance, suggesting age-related antioxidant upregulation.

This study finds that GABA levels decrease with age in the ventral visual cortex and are linked to reduced neural distinctiveness in older adults.

This study examines how a spaceflight analog environment with elevated CO2 affects brain connectivity and sensorimotor performance over time.

This study shows that older adults show less distinct neural activation patterns in auditory cortex and lower GABA levels, with GABA levels predicting neural distinctiveness in older adults.

The MiND project investigates age-related neural dedifferentiation by examining its scope, causes, and behavioral consequences using multimodal imaging and behavioral measures.