Kathleen E. Hupfeld

Age dependency of neurometabolite T1 relaxation times

The paper measures metabolite T1 relaxation times in healthy adults across age groups and finds age-related decreases in several metabolites in specific brain regions.

Metabolite T2 relaxation times decrease across the adult lifespan in a large multi-site cohort

The paper investigates age-related changes in metabolite T2 relaxation times across the adult lifespan in a multi-site cohort, finding significant declines in several metabolites with aging.

A Water Relaxation Atlas for Age and Region specific Metabolite Concentration Correction

This paper develops a water relaxation atlas to correct metabolite concentrations in MRS by integrating age and region-specific relaxation values into the analysis workflow.

Comparison of test-retest reproducibility of DESPOT and 3D-QALAS for water T1 and T2 mapping

This study compares the test-retest reproducibility of DESPOT and QALAS for T1 and T2 mapping in healthy volunteers, finding QALAS provides better reproducibility and reduced acquisition time.

Model-based frequency-and-phase correction of 1H MRS data with 2D linear-combination modeling.

This paper introduces a model-based frequency-and-phase correction method for 1H MRS data using 2D linear-combination modeling, showing improved performance over traditional approaches at low SNR.

Brain Glutathione and GABA+ levels in autistic children

This study found no significant differences in cerebral glutathione or GABA levels between autistic children and typically developing children, but found a positive correlation between GABA levels and ADHD inattention scores.

Impact of acquisition and modeling parameters on test-retest reproducibility of edited GABA+

This study evaluates how acquisition and modeling parameters affect test-retest reproducibility of GABA+ measurements using edited MRS, finding that model selection significantly impacts reproducibility.

Application of a 1H Brain MRS Benchmark Dataset to Deep Learning for Out-of-Voxel Artifacts

This paper introduces AGNOSTIC, a synthetic 1H MRS dataset for training deep learning models to detect and predict out-of-voxel echoes in brain MRS data.

Impacts of Spaceflight Experience on Human Brain Structure

This study examines how spaceflight duration and prior experience affect brain structure in astronauts, finding greater ventricular expansion and white matter decline with longer missions and more prior flights.

Daily Artificial Gravity is Associated with Greater Neural Efficiency during Sensorimotor Adaptation

This study shows that daily artificial gravity reduces brain activation during sensorimotor adaptation compared to head-down tilt bed rest.

sLASER and PRESS Perform Similarly at Revealing Metabolite-Age Correlations

This study compares PRESS and sLASER for detecting metabolite-age correlations in brain regions, finding similar results despite technical differences.

Metabolite T1 relaxation times differ across the adult lifespan

The paper examines age-related changes in metabolite T1 relaxation times in brain regions using a cross-sectional dataset and finds significant decreases in white-matter-rich areas with age.

Neurometabolic timecourse of healthy aging

The paper investigates neurometabolic changes with age using MR spectroscopy in a cross-sectional cohort, finding age correlations for several metabolites but not others.

Sensory system-specific associations between brain structure and balance

This study examines how brain structure relates to balance in young and older adults under different sensory conditions, finding associations between cortical thickness, gyrification, and white matter microstructure with balance performance.

Differential relationships between brain structure and dual task walking in young and older adults

This study examines how brain structure relates to dual task walking in young and older adults, finding age-specific associations between brain atrophy and gait performance during cognitive tasks.

The effects of long duration spaceflight on sensorimotor control and cognition

This study examines how long-duration spaceflight affects sensorimotor control and cognition, finding transient declines in mobility, balance, and bimanual coordination that recover within 30 days, while cognitive performance remains stable.

MRI-Visible Perivascular Space (PVS) Changes with Long-Duration Spaceflight

This study examines how spaceflight affects MRI-visible perivascular spaces (PVSs) in astronauts, finding that novice astronauts show increased PVS volume post-flight, while experienced astronauts show baseline correlations between flight days and PVS length.

In Vivo Brain Glutathione is Higher in Older Age and Correlates with Mobility

This study finds higher brain glutathione levels in older adults and links sensorimotor GSH to poorer motor performance, suggesting age-related antioxidant upregulation.