Author

Aslihan Shenol

University of CopenhagenORCID 0000-0003-2508-3335Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:deep learning· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:simulation· 1

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Jacob Emil PeterseniD· 1 shared James Andrew McCammoniD· 1 shared Michael LückmanniD· 1 shared Thomas M. FrimureriD· 1 shared Thue Walter SchwartziD· 1 shared Wen MaiD· 1 shared

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2025-2025 · peak 1/yr

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1 shared paperBiophysics

Jacob Emil PetersenORCID

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1 paper

Recent·Most cited

BiophysicsbioRxivPreprintJun 8, 2025

Constitutive activation and allosteric mechanisms underlying Gi/Gq signaling bias in SUCNR1 revealed by AlphaFold-based modeling and enhanced sampling simulations

Aslihan Shenol, Jacob Emil Petersen, Michael Lückmann…·Wen Ma

This study uses AlphaFold and simulations to show human SUCNR1 spontaneously adopts active conformations and exhibits constitutive signaling, while murine SUCNR1 requires agonist for activation.

DOI 10.1101/2025.06.08.658530

humanmouse

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