Author

Thomas M. Frimurer

University of CopenhagenORCID 0000-0002-9682-8245Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Approach:simulation· 1 Organism:yeast· 1

Frequent Co-Authors

Agustina UndabarrenaiD· 1 shared Antonio Di PietroiD· 1 shared Aslihan ShenoliD· 1 shared Emil D. JenseniD· 1 shared Emma Elise Hoch-SchneideriD· 1 shared Giovanni SchiesaroiD· 1 shared Jacob Emil PeterseniD· 1 shared James Andrew McCammoniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperSynthetic Biology

Agustina UndabarrenaORCID

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2 papers

Recent·Most cited

A yeast mating platform for multiplex screening of fungal GPCR-ligand interactions

Giovanni Schiesaro, Melani Mariscal, Mathias Jönsson, Ricardo Tenente, Mathies Brinks Sørensen, Marcus Wäneskog, María Victoria Aguilar Pontes, Agustina Undabarrena, Marcus Deichmann, Emma Elise Hoch-Schneider, Vijayalakshmi Kandasamy, Thomas M. Frimurer, Antonio Di Pietro, Line Katrine Harder Clemmensen, Michael Krogh Jensen, Emil D. Jensen

The paper develops a yeast mating platform to screen fungal GPCR-ligand interactions and identifies peptides that modulate fungal communication.

Proceedings of the National Academy of Sciences · Oct 24, 2025Peer-reviewedSynthetic Biology

Constitutive activation and allosteric mechanisms underlying Gi/Gq signaling bias in SUCNR1 revealed by AlphaFold-based modeling and enhanced sampling simulations

Aslihan Shenol, Jacob Emil Petersen, Michael Lückmann, Thomas M. Frimurer, James Andrew McCammon, Thue Walter Schwartz, Wen Ma

This study uses AlphaFold and simulations to show human SUCNR1 spontaneously adopts active conformations and exhibits constitutive signaling, while murine SUCNR1 requires agonist for activation.

bioRxiv · Jun 8, 2025 · PreprintBiophysics