Thue Walter Schwartz

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of interorganellar lipid cycling

This paper identifies SLC25A34 as a key regulator of interorganellar lipid cycling, integrating circadian rhythms, diet, and temperature to control thermogenic metabolism.

Constitutive activation and allosteric mechanisms underlying Gi/Gq signaling bias in SUCNR1 revealed by AlphaFold-based modeling and enhanced sampling simulations

This study uses AlphaFold and simulations to show human SUCNR1 spontaneously adopts active conformations and exhibits constitutive signaling, while murine SUCNR1 requires agonist for activation.

Systems analysis of metabolic responses to a mixed meal test in an obese cohort reveals links between tissue metabolism and the gut microbiota

The paper analyzes metabolic responses to a mixed meal test in an obese cohort, linking tissue metabolism with gut microbiota changes and identifying potential biomarkers for T2DM.

Rfx6 promotes the differentiation of peptide-secreting enteroendocrine cells while repressing genetic programs controlling serotonin production

This study identifies Rfx6 as a key regulator of enteroendocrine cell differentiation, promoting peptidergic cells while repressing serotonin-producing cells.