Author

Jacqueline E. Broome

University at Buffalo, State University of New YorkORCID 0000-0003-2515-1537Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Fraser J. SimiD· 2 shared Jessie J. PolancoiD· 2 shared Richard A. SeidmaniD· 2 shared Ajai K. TripathiiD· 1 shared Darpan SaraswatiD· 1 shared Hani J. ShayyaiD· 1 shared Heba Khattab· 1 shared Joanna J. PhillipsiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Fraser J. SimORCID

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2 papers

Recent·Most cited

NeuroscienceScientific ReportsPeer-reviewedApr 13, 2022

Oscillatory calcium release and sustained store-operated oscillatory calcium signaling prevents differentiation of human oligodendrocyte progenitor cells

Richard A. Seidman, Heba Khattab, Jessie J. Polanco…·Fraser J. Sim

This study shows that Gq-coupled receptor activation induces oscillatory calcium signaling in hOPCs, which blocks differentiation and promotes proliferation through SOCE, suggesting potential therapeutic targets for myelin repair.

16 citations

humanstatistical model

𝕏 PostBluesky

NeuroscienceNature CommunicationsPeer-reviewedMar 26, 2021

Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following demyelination

Darpan Saraswat, Hani J. Shayya, Jessie J. Polanco…·Fraser J. Sim

This study identifies Sulf1/2 as a key inhibitor of oligodendrocyte progenitor cell recruitment and remyelination in chronic demyelination, showing that sulfatase inhibition can enhance remyelination.

31 citations

humanbulk RNA-seq

𝕏 PostBluesky