Author

Richard A. Seidman

University at Buffalo, State University of New YorkORCID 0000-0002-7151-6413Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Fraser J. SimiD· 2 shared Jacqueline E. BroomeiD· 2 shared Jessie J. PolancoiD· 2 shared Ajai K. TripathiiD· 1 shared Darpan SaraswatiD· 1 shared Hani J. ShayyaiD· 1 shared Heba Khattab· 1 shared Joanna J. PhillipsiD· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Fraser J. SimORCID

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2 papers

Recent·Most cited

Oscillatory calcium release and sustained store-operated oscillatory calcium signaling prevents differentiation of human oligodendrocyte progenitor cells

Richard A. Seidman, Heba Khattab, Jessie J. Polanco, Jacqueline E. Broome, Fraser J. Sim

This study shows that Gq-coupled receptor activation induces oscillatory calcium signaling in hOPCs, which blocks differentiation and promotes proliferation through SOCE, suggesting potential therapeutic targets for myelin repair.

Scientific Reports · Apr 13, 2022Peer-reviewedNeuroscience

Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following demyelination

Darpan Saraswat, Hani J. Shayya, Jessie J. Polanco, Ajai K. Tripathi, R. Ross Welliver, Suyog U. Pol, Richard A. Seidman, Jacqueline E. Broome, Melanie A. O’Bara, Toin H. Van Kuppevelt, Joanna J. Phillips, Ranjan Dutta, Fraser J. Sim

This study identifies Sulf1/2 as a key inhibitor of oligodendrocyte progenitor cell recruitment and remyelination in chronic demyelination, showing that sulfatase inhibition can enhance remyelination.

Nature Communications · Mar 26, 2021Peer-reviewedNeuroscience