Jessie J. Polanco

This study shows that chronic demyelination in rabbit CNS is associated with reduced oligodendrocyte progenitor cell (OPC) repopulation, regardless of lesion size, and highlights species-specific differences in remyelination mechanisms.

This study shows that Gq-coupled receptor activation induces oscillatory calcium signaling in hOPCs, which blocks differentiation and promotes proliferation through SOCE, suggesting potential therapeutic targets for myelin repair.

This study identifies Sulf1/2 as a key inhibitor of oligodendrocyte progenitor cell recruitment and remyelination in chronic demyelination, showing that sulfatase inhibition can enhance remyelination.