Author

Ajai K. Tripathi

Cleveland ClinicORCID 0000-0002-5070-2567Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Approach:experimental assay· 1 Assay:metabolomics· 1 Organism:mouse· 1

Frequent Co-Authors

Ranjan DuttaiD· 3 shared Aaron Perles· 1 shared Arthur Anthony Reyes· 1 shared Bardia NourbakhshiD· 1 shared Christina M. Volsko· 1 shared Claire E. Jones· 1 shared Darpan SaraswatiD· 1 shared Elias S. SotirchosiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersNeuroscience

Ranjan DuttaORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 17, 2023

Dicer deficiency in microglia leads to accelerated demyelination and failed remyelination

Ajai K. Tripathi, Nagendra Rai, Aaron Perles…·Ranjan Dutta

This study shows that Dicer deficiency in microglia accelerates demyelination and impairs remyelination by affecting oligodendrocyte progenitor cells and microglial function.

DOI 10.1101/2023.10.17.562812

mouseexperimental assay

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NeuroscienceNature CommunicationsPeer-reviewedMar 26, 2021

Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following demyelination

Darpan Saraswat, Hani J. Shayya, Jessie J. Polanco…·Fraser J. Sim

This study identifies Sulf1/2 as a key inhibitor of oligodendrocyte progenitor cell recruitment and remyelination in chronic demyelination, showing that sulfatase inhibition can enhance remyelination.

31 citations

humanbulk RNA-seq

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NeuroscienceJournal of Clinical InvestigationPeer-reviewedMar 17, 2020

Bile acid metabolism is altered in multiple sclerosis and supplementation ameliorates neuroinflammation

Pavan Bhargava, Matthew D. Smith, Leah Mische…·Peter A. Calabresi

This study shows bile acid metabolism is altered in multiple sclerosis, and supplementation with tauroursodeoxycholic acid reduces neuroinflammation in animal models.

237 citationstop 1%

humanmetabolomics

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