Author

Roger J. Hajjar

Icahn School of Medicine at Mount SinaiORCID 0000-0003-2522-1507Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandra DainisiD· 1 shared Alexandre J. S. RibeiroiD· 1 shared Alice Cheung· 1 shared Andy O.-T. Wong· 1 shared Anna WalentinssoniD· 1 shared Beth L. PruittiD· 1 shared Ching Shang· 1 shared Cláudia CorreiaiD· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperMolecular Biology

Alexandra DainisORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintAug 27, 2024

Reversal of contractile defects by mediating calcium homeostasis in human mini-heart models of heart failure with preserved ejection fraction (HFpEF) leads to first-in-human gene therapy clinical trial

Kevin D. Costa, Andy O.-T. Wong, Suet Yee Mak…·Ronald A. Li

This paper develops human mini-heart models of HFpEF, identifies SERCA2a downregulation, and demonstrates gene therapy efficacy, leading to a first-in-human clinical trial.

5 citations

humanbulk RNA-seq

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Molecular BiologyCirculationPeer-reviewedJul 18, 2019

Allele-specific silencing ameliorates restrictive cardiomyopathy due to a human myosin regulatory light chain mutation

Kathia Zaleta-Rivera, Alexandra Dainis, Alexandre J. S. Ribeiro…·Euan Angus Ashley

This paper demonstrates that allele-specific RNAi therapy reduces disease-causing mutations in a mouse model of restrictive cardiomyopathy, improving cardiac function and reducing pathological markers.

50 citationstop 5%

mouseproteomics

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