Stefano R. Bonissone

This study benchmarks mass spectrometry-based antibody sequencing methods, revealing biases related to sequence, concentration, protease, and bioinformatics tools.

The paper identifies high-affinity anti-SARS-CoV-2 antibodies in serum and B cells from donors with hybrid immunity, showing convergence and cross-reactivity against emerging variants.

The paper introduces AbScan, a proteogenomic method to identify antibody peptides from RNA-seq data, and applies it to colorectal cancer samples to find correlations between antibody peptides and survival.