Khang Lê Quý

Influenza H1N1 Imprinting Uncouples Serological and B-Cell Responses in Mice

This study shows that immunological imprinting in mice uncouples serological and B-cell responses, with B-cell repertoires updating independently of serum antibody specificity.

MS-BCR-DB: an integrated BCR repertoire database to mine humoral multiple sclerosis signatures

The paper develops MS-BCR-DB, a unified BCR repertoire database for MS, identifying disease-associated features and shared clonotypes across patients.

Systematic benchmarking of mass spectrometry-based antibody sequencing reveals methodological biases

This study benchmarks mass spectrometry-based antibody sequencing methods, revealing biases related to sequence, concentration, protease, and bioinformatics tools.

Biophysical cartography of the native and human-engineered antibody landscapes quantifies the plasticity of antibody developability

The paper quantifies the plasticity of antibody developability by analyzing sequence and structure-based parameters in natural and human-engineered antibodies.

Simple computational methods can outperform deep learning in designing diverse, binder-enriched antibody libraries

The paper shows that simple computational methods like BLOSUM can create diverse, binder-enriched antibody libraries better than deep learning approaches.