NeuroscienceTranslational PsychiatryPeer-reviewed
The Effects of Bipolar Disorder Granule Cell Hyperexcitability and Lithium Therapy on Pattern Separation in a Computational Model of the Dentate Gyrus
Selena Singh, Anouar Khayachi, Shani Stern…·Abraham Nunes
This study uses a computational model of the dentate gyrus to show that lithium therapy improves pattern separation in bipolar disorder patients only by normalizing spontaneous activity, not by reducing cell excitability.
5 citations