The Effects of Bipolar Disorder Granule Cell Hyperexcitability and Lithium Therapy on Pattern Separation in a Computational Model of the Dentate Gyrus
Selena Singh, Anouar Khayachi, Shani Stern, Thomas P. Trappenberg, Martin Alda, Abraham Nunes
This study uses a computational model of the dentate gyrus to show that lithium therapy improves pattern separation in bipolar disorder patients only by normalizing spontaneous activity, not by reducing cell excitability.
Translational Psychiatry · Oct 6, 2025Peer-reviewedNeuroscience