Jordan J. Feld

The paper identifies two distinct CD8 T cell gene expression programs in HBV infection that correlate with viral control and functional cure.

The paper shows that chronic inflammation in the liver leads to the formation of long-lived inflammatory macrophages derived from monocytes, which retain an inflammatory profile and may drive liver disease progression.

The paper develops a multiplex probe panel strategy to improve clinical sensitivity for detecting mutating viruses, achieving 89% sensitivity for hepatitis C virus.

The paper identifies a Neandertal introgressed haplotype in the OAS1 gene associated with increased risk of severe COVID-19 and shows it impairs SARS-CoV-2 clearance through genetic regulation of OAS1 expression.