Adam J. Gehring

The paper identifies two distinct CD8 T cell gene expression programs in HBV infection that correlate with viral control and functional cure.

The paper shows that chronic inflammation in the liver leads to the formation of long-lived inflammatory macrophages derived from monocytes, which retain an inflammatory profile and may drive liver disease progression.

The paper identifies fetal pancreatic macrophage subsets and shows their role in promoting endocrine cell differentiation and tissue engraftment.

The paper identifies a Neandertal introgressed haplotype in the OAS1 gene associated with increased risk of severe COVID-19 and shows it impairs SARS-CoV-2 clearance through genetic regulation of OAS1 expression.