Georg M. Lauer

Decoding & manipulating human intercellular signaling via scalable cell-free protein synthesis

The paper develops scalable cell-free protein synthesis platforms to generate single-cell RNA-sequencing data on immune cell responses to cytokines and other signals, enabling functional discovery and drug target prioritization.

The conserved bridging domain on HCV E1E2 glycoprotein complex is targeted by neutralizing antibodies from diverse lineages

This study identifies the conserved bridging domain on HCV E1E2 as a target for neutralizing antibodies from diverse lineages, showing additivity with neutralizing face antibodies.

Hepatic CD8+TOX+ T-cells are a hallmark of autoimmune hepatitis

This study identifies CD8+TOX+ T-cells as a specific marker for autoimmune hepatitis using single-nucleus RNA sequencing.

NK-like and networked CD8+ T cell immunity mediates exceptional HIV control

The paper identifies an NK-like KIR CD8 T cell subset as a key feature of exceptional HIV control, complementing networked epitope targeting for immunotherapeutic strategies.

HLiCA: An integrated cell atlas of the healthy human liver

The paper integrates multiple datasets to create a comprehensive human liver cell atlas, identifying new cell types and associations with demographic factors.

CD8 T cells with classical and NK-like cytotoxic gene expression programs mediate control of HBV replication and functional cure

The paper identifies two distinct CD8 T cell gene expression programs in HBV infection that correlate with viral control and functional cure.

DNA-barcode labelled MHCII multimers for detection of antigen-specific CD4 T cells across large libraries of epitopes

This paper introduces a DNA-barcode labelled MHCII multimer method to detect antigen-specific CD4 T cells across large epitope libraries and identifies 12 novel HCV epitopes.

Chronic metabolic stress drives developmental programs and loss of tissue functions in non-transformed liver that mirror tumor states and stratify survival

The paper shows chronic metabolic stress in liver cells drives developmental programs and functional loss, mirroring tumor states and predicting poor cancer survival.

B cell transcriptomics reveals lasting dysregulation and rapid decline of protective memory after hepatitis C cure

This study shows that B cells in hepatitis C patients retain dysregulated transcriptional profiles after cure, with sustained TNF signaling driving chronic inflammation and loss of protective memory.