Daniel Traum

A universal platform for simultaneous TCRα/β removal enables safer and more potent TCR therapies and autoimmune modeling

This paper presents a CRISPR-based platform that removes endogenous TCRα/β chains to enhance transgenic TCR function and safety in T-cell therapies and autoimmune modeling.

Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the fibrotic microenvironment in kidney disease progression

Multi-omic and spatial profiling of 81 human kidney samples resolves four tissue microenvironments; the fibrotic one's gene signature is reported to beat histopathology at predicting outcome.

Single-cell analysis of the human pancreas in type 2 diabetes using multi-spectral imaging mass cytometry

This study uses imaging mass cytometry to analyze pancreatic cells in T2D patients and controls, revealing changes in islet structure, cell composition, and immune cell infiltration.

Multiomics single-cell analysis of human pancreatic islets reveals novel cellular states in health and type 1 diabetes