Author

James T. O’Connor

Washington University in St. LouisORCID 0000-0003-2642-1594Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Joseph BloomiD· 1 shared Aaron D. GitleriD· 1 shared Aaron DiAntonioiD· 1 shared Caiwei GuoiD· 1 shared Dennis W. DicksoniD· 1 shared Hui Qi Loo· 1 shared Jeffrey MilbrandtiD· 1 shared Leonard PetrucelliiD· 1 shared

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2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

A. Joseph BloomORCID

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1 paper

Recent·Most cited

NeurosciencebioRxivPreprintNov 21, 2025

TDP-43 suppression of ATP8A2 cryptic splicing implicates phosphatidylserine-driven neuroinflammation in ALS/FTD

James T. O’Connor, Hui Qi Loo, Caiwei Guo…·Aaron DiAntonio

This study identifies ATP8A2 as a TDP-43 target whose loss leads to PS exposure and neuroinflammation, suggesting immune cell inhibition as a therapeutic strategy for ALS-FTD and CAMRQ4.

2 citations

mousehuman

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