Ran Wang

The paper introduces a modular framework for designing eukaryotic transcription factors by separating functional domains and using synthetic promoters to control gene regulation.

The paper identifies a pre-marked enhancer, p-Enh, that primes posterior tissue development in mouse embryos through interaction with the TGF-β signaling pathway.

The paper constructs a single-cell spatio-temporal atlas of molecular trajectories during gastrulation in mouse embryos, revealing asymmetric BMP signaling and its role in left-right body plan asymmetry.