Naihe Jing

The paper shows that the cloacal outgrowth coordinates bladder and umbilical artery development through Shh and Wnt2 signals in humans and mice.

This study constructs a spatiotemporal regulatory framework for mouse gastrulation using multi-omic data and reveals mechanisms of lineage commitment and symmetry breaking.

The paper introduces Palette, a method to infer spatial gene expression from bulk RNA-seq data, and constructs DreSTEP, a resource for studying gene expression and spatial interactions in zebrafish embryos.

This study identifies Smarcc1's role in optic stalk development and optic nerve head astrocyte differentiation, showing its necessity for morphogenesis and RGC survival.

The paper shows that asynchronous polarization in mouse embryos leads to heterogeneity in cell fate specification, linking early 4-cell stage asymmetries to later 8-cell stage lineage decisions.

The paper identifies a pre-marked enhancer, p-Enh, that primes posterior tissue development in mouse embryos through interaction with the TGF-β signaling pathway.

This study identifies lncRNA-Gm26793 as a key regulator of stem cell differentiation and mouse embryogenesis through an inter-chromosomal interaction with Cubn.

The paper identifies mesendoderm progenitor cells in mouse embryos and shows their contribution to endoderm and mesoderm lineages through lineage tracing and analysis of Mixl1 function.

The paper uses single-cell multi-omics to study early cardiac lineage specification in mouse embryos, identifying key transcription factors and regulatory networks.

The paper constructs a single-cell spatio-temporal atlas of molecular trajectories during gastrulation in mouse embryos, revealing asymmetric BMP signaling and its role in left-right body plan asymmetry.

This study identifies Nr2f1 and Nr2f2 as critical regulators of hippocampal dorsoventral axis differentiation and integration in mice.

The paper maps spatial and molecular changes in germ layers during primate gastrulation using spatial transcriptomics and 3D modeling.

The paper maps cardiac differentiation at single-cell resolution, identifies HOPX dysregulation, and shows hypertrophic signaling is required for HOPX transcription in hPSC-derived cardiomyocytes.