Author

Samuel JK Abraham

University of Yamanashi HospitalORCID 0000-0003-2646-2687Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 3 Genetic & Genomic Medicine· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Rajappa SenthilkumariD· 6 shared Senthilkumar PreethyiD· 6 shared Masaru IwasakiiD· 4 shared Naoki YamamotoiD· 4 shared Kadalraja Raghavan· 3 shared Koji Ichiyama· 3 shared Vidyasagar Devaprasad Dedeepiya· 3 shared Nobunao IkewakiiD· 2 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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6 shared papersGenetics

Rajappa SenthilkumarORCID

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6 papers

Recent·Most cited

Synthetic BiologyFrontiers in UrologyPeer-reviewedJan 14, 2026

A hybrid combination of in vitro cultured buccal mucosal cells using two different methodologies, complementing each other in successfully repairing a stricture-inflicted human male urethral epithelium

Akio Horiguchi, Toshihiro Kushibiki, Yoshine Mayumi…·Samuel J. K. Abraham

The paper describes a hybrid cell culture method combining 2D and 3D cultured cells from human buccal tissue to repair urethral stricture, showing increased epithelial markers in 3D cultures and higher IGF-1 secretion in 2D cultures.

2 citations

humanproteomics

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GeneticsScientific ReportsPeer-reviewedFeb 28, 2025

Enhanced expression of Dystrophin, IGF-1, CD44 and MYH3 in plasma and skeletal muscles including Diaphragm of mdx mice after oral administration of Neu REFIX Beta 1,3-1,6 glucan

Senthilkumar Preethy, Shuji Sakamoto, Takuma Higuchi…·Samuel JK Abraham

6 citations

mouseproteomics

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GeneticsbioRxivPreprintSep 25, 2023

Reduction in myocardial fibrosis in MDX mice on oral consumption of Aureobasidium Pullulans produced Neu REFIX Beta-glucans; holds potential as an adjuvant in managing post-transplantation organ fibrosis

Senthilkumar Preethy, Naoki Yamamoto, Kothurathu Mammen Cherian…·Samuel JK Abraham

The paper evaluates the anti-fibrotic effects of Neu-REFIX beta-glucan on myocardial fibrosis in mdx mice, showing a significant reduction in collagen type I.

1 citation

mouseexperimental assay

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Genetic & Genomic MedicinemedRxivPreprintJul 20, 2023

Efficacy of N-163 beta-glucan in beneficially improving biomarkers of relevance to muscle function in patients with muscular dystrophies in a pilot clinical study

Kadalraja Raghavan, Thanasekar Sivakumar, Koji Ichiyama…·Samuel JK Abraham

DOI 10.1101/2023.07.20.23292982

humanexperimental assay

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Genetic & Genomic MedicinemedRxivPreprintDec 9, 2022

Randomised trial of Aureobasidium pullulans-produced beta 1,3-1,6-glucans in patients with Duchenne muscular dystrophy: Favourable changes in gut microbiota and clinical outcomes indicating their potential in epigenetic manipulation

Kadalraja Raghavan, Vidyasagar Devaprasad Dedeepiya, Naoki Yamamoto…·Samuel JK Abraham

A pilot study examines the effects of Aureobasidium pullulans-produced beta 1,3-1,6-glucans on gut microbiota and clinical outcomes in Duchenne muscular dystrophy patients, showing beneficial microbiome changes and anti-inflammatory effects.

11 citations

humanmetagenomics

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GeneticsbioRxivPreprintNov 17, 2022

Resolution of fibrosis in mdx dystrophic mouse after oral consumption of N-163 strain of Aureobasidium pullulans produced biological response modifier β-glucan (BRMG)`

Senthilkumar Preethy, Yoshitsugu Aoki, Katsura Minegishi…·Samuel JK Abraham

This study evaluates the anti-inflammatory and anti-fibrotic effects of N-163 β-glucan in mdx dystrophic mice, showing reduced fibrosis and inflammation markers.

5 citations

mousebulk RNA-seq

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